Synonym(s): - Adynamia episodica hereditaria - Familial hyperPP - Familial hyperkalemic periodic paralysis - Gamstorp disease - Gamstorp episodic adynamy - HYPP - HyperKPP - HyperPP - Hyperkalemic PP - Primary hyperPP - Primary hyperkalemic periodic paralysis
Classification (Orphanet): - Rare genetic disease - Rare neurologic disease Entire classification		Classification (ICD10): - Diseases of the nervous system - See
Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: childhood Average age of death: normal Type of inheritance: autosomal dominant		External references: 1 OMIM reference - See 2 MeSH references: C535409 / D020513
More Info - Orphanet

Gene symbol	UniProt reference	OMIM reference
SCN4A	P35499	603967

- Abnormal EMG / electromyogram / electropmyography
- Abnormal muscle biopsy / muscle enzymes / CPK / LDH / aldolase / creatin phosphokinase
- Acute palsy
- Areflexia / hyporeflexia
- Autosomal dominant inheritance
- Muscle weakness / flaccidity

- Abnormal gait
- Hyperkalemia
- Myalgia / muscular pain
- Myoclonus / fasciculations
- Myotonia

- Cardiac rhythm disorder / arrhythmia
- Contractures / cramps / trismus / tetania / claudication / opisthotonos
- Death in infancy
- Early death in adulthood
- Encopresis / fecal incontinence
- Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia
- Heart / cardiac failure
- Hypertonia / spasticity / rigidity / stiffness
- Hypokalemia
- Hyponatremia
- Intestinal transit disorder
- Malignant hyperthermia
- Muscle hypertrophy
- Muscle hypotrophy / atrophy / dystrophy / agenesis / amyotrophy
- Myopathy
- Ophthalmoplegia / ophthalmoparesis / oculomotor palsy
- Paresthesia / dysesthesia / hypoesthesia / anesthesia / numbness
- Respiratory distress / dyspnea / respiratory failure / lung volume reduction
- Thoracic / chest pain